AKT -> p38 p38 -> p38 p53 -| CyclinB1 CyclinB1 -> CyclinB1 TSC2 -> TSC2 ERK1_2 -| TSC2 AKT -| TSC2 GSKa_b -| TSC2 RB -> TSC2 ERBB2 -> AKT AKT -> AKT ERBB3 -> AKT ERBB1 -> AKT CyclinB1 -> AKT PTEN -| AKT RPS6 -> ERBB3 ERBB3 -> ERBB3 pertuzumab -| ERBB3 erlotinib -| ERBB3 stimulus -> ERBB3 AKT -| PRAS cJUN -> PRAS PRAS -> PRAS RPS6 -> RPS6 p70S6K -> RPS6 p53 -> RB RB -> RB CyclinB1 -| RB ERBB3 -> ERBB1 cJUN -> ERBB1 ERBB1 -> ERBB1 pertuzumab -| ERBB1 erlotinib -| ERBB1 stimulus -> ERBB1 ERBB2 -> ERBB2 pertuzumab -| ERBB2 erlotinib -| ERBB2 stimulus -> ERBB2 trastuzumab -| ERBB2 ERBB2 -> cRAF ERK1_2 -| cRAF ERBB1 -> cRAF cRAF -> cRAF Nfkb -> Nfkb p53 -> p53 RB -> p53 CyclinB1 -> p53 p38 -> p53 p53 -> GSKa_b GSKa_b -> GSKa_b ERK1_2 -> ERK1_2 ERBB1 -> ERK1_2 cRAF -> ERK1_2 GSKa_b -| cJUN cJUN -> cJUN GSKa_b -| PTEN PTEN -> PTEN cRAF -> PTEN TSC2 -| p70S6K ERK1_2 -> p70S6K p70S6K -> p70S6K PRAS -| p70S6K AKT -| FOXO1_3a FOXO1_3a -> FOXO1_3a BAX -> BAX ERK1_2 -> CyclinD1 AKT -> CyclinD1 cJUN -> CyclinD1 CyclinD1 -> CyclinD1 p70S6K -> CyclinD1 $AKT: (((((ERBB2 & !PTEN) | (AKT & !PTEN)) | (CyclinB1 & !PTEN)) | (ERBB3 & !PTEN)) | (ERBB1 & !PTEN)) $BAX: BAX $CyclinB1: (CyclinB1 & !p53) $CyclinD1: ((((CyclinD1 | ERK1_2) | cJUN) | AKT) | p70S6K) $ERBB1: ((((ERBB1 & !(pertuzumab | erlotinib)) | (cJUN & !(pertuzumab | erlotinib))) | (stimulus & !(pertuzumab | erlotinib))) | (ERBB3 & !(pertuzumab | erlotinib))) $ERBB2: ((ERBB2 & !((trastuzumab | pertuzumab) | erlotinib)) | (stimulus & !((trastuzumab | pertuzumab) | erlotinib))) $ERBB3: (((stimulus & !(erlotinib | pertuzumab)) | (RPS6 & !(erlotinib | pertuzumab))) | (ERBB3 & !(erlotinib | pertuzumab))) $ERK1_2: ((ERK1_2 | cRAF) | ERBB1) $FOXO1_3a: (FOXO1_3a & !AKT) $GSKa_b: (p53 | GSKa_b) $Nfkb: Nfkb $PRAS: ((PRAS & !AKT) | (cJUN & !AKT)) $PTEN: ((cRAF & !GSKa_b) | (PTEN & !GSKa_b)) $RB: ((p53 & !CyclinB1) | (RB & !CyclinB1)) $RPS6: (p70S6K | RPS6) $TSC2: ((RB & !((GSKa_b | ERK1_2) | AKT)) | (TSC2 & !((GSKa_b | ERK1_2) | AKT))) $cJUN: (cJUN & !GSKa_b) $cRAF: (((ERBB2 & !ERK1_2) | (ERBB1 & !ERK1_2)) | (cRAF & !ERK1_2)) $p38: (p38 | AKT) $p53: (((RB | p53) | p38) | CyclinB1) $p70S6K: ((p70S6K & !(TSC2 | PRAS)) | (ERK1_2 & !(TSC2 | PRAS)))